Biochemical Correction post-HSCT
Patients 1, 2 and 4, who maintained 100% chimerism, also showed
sustained biochemical correction post-HSCT (normal deoxyuridine and
thymidine levels in blood). Patient 3, who died 12 days after
transplant, showed no biochemical correction. For patients 5 and 6 who
had secondary engraftment failure, whereas 23 days post-transplant
patient 5 had essentially normal results, nucleoside levels 18 and 14
months post-transplant, respectively, were elevated (all details are
summarized in Table 2).