References
1. Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology.Nat Rev Genet. 2004;5(10):725-738.
2. Loane M, Morris JK, Addor MC, et al. Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening. Eur J Hum Genet.2013;21(1):27-33.
3. de Groot-van der Mooren MD, Tamminga S, Oepkes D, Weijerman ME, Cornel MC. Older mothers and increased impact of prenatal screening: stable livebirth prevalence of trisomy 21 in the Netherlands for the period 2000-2013. Eur J Hum Genet. 2018;26(2):157-165.
4. Rodman R, Pine HS. The otolaryngologist’s approach to the patient with Down syndrome. Otolaryngol Clin North Am.2012;45(3):599-629, vii-viii.
5. Hamilton J, Yaneza MM, Clement WA, Kubba H. The prevalence of airway problems in children with Down’s syndrome. Int J Pediatr Otorhinolaryngol. 2016;81:1-4.
6. Stoll C, Dott B, Alembik Y, Roth MP. Associated congenital anomalies among cases with Down syndrome. Eur J Med Genet.2015;58(12):674-680.
7. Maris M, Verhulst S, Wojciechowski M, Van de Heyning P, Boudewyns A. Prevalence of Obstructive Sleep Apnea in Children with Down Syndrome.Sleep. 2016;39(3):699-704.
8. Lee CF, Lee CH, Hsueh WY, Lin MT, Kang KT. Prevalence of Obstructive Sleep Apnea in Children With Down Syndrome: A Meta-Analysis. J Clin Sleep Med. 2018;14(5):867-875.
9. Beckhaus AA, Castro-Rodriguez JA. Down Syndrome and the Risk of Severe RSV Infection: A Meta-analysis. Pediatrics. 2018;142(3).
10. Ram G, Chinen J. Infections and immunodeficiency in Down syndrome.Clin Exp Immunol. 2011;164(1):9-16.
11. Galleguillos C, Galleguillos B, Larios G, Menchaca G, Bont L, Castro-Rodriguez JA. Down’s syndrome is a risk factor for severe lower respiratory tract infection due to respiratory syncytial virus.Acta Paediatr. 2016;105(11):e531-e535.
12. Goffinski A, Stanley MA, Shepherd N, et al. Obstructive sleep apnea in young infants with Down syndrome evaluated in a Down syndrome specialty clinic. Am J Med Genet A. 2015;167A(2):324-330.
13. Chamseddin BH, Johnson RF, Mitchell RB. Obstructive Sleep Apnea in Children with Down Syndrome: Demographic, Clinical, and Polysomnographic Features. Otolaryngol Head Neck Surg. 2019;160(1):150-157.
14. Pandit C, Fitzgerald DA. Respiratory problems in children with Down syndrome. J Paediatr Child Health. 2012;48(3):E147-152.
15. Kaditis AG. Management of sleep-disordered breathing in children with complex disorders: One size does not fit all. Pediatr Pulmonol. 2018;53(10):1333-1335.
16. Alsubie HS, Rosen D. The evaluation and management of respiratory disease in children with Down syndrome (DS). Paediatr Respir Rev.2018;26:49-54.
17. Horne RS, Wijayaratne P, Nixon GM, Walter LM. Sleep and sleep disordered breathing in children with down syndrome: Effects on behaviour, neurocognition and the cardiovascular system. Sleep Med Rev. 2019;44:1-11.
18. Marcus CL, Moore RH, Rosen CL, et al. A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med.2013;368(25):2366-2376.
19. Best J, Mutchnick S, Ida J, Billings KR. Trends in management of obstructive sleep apnea in pediatric patients with Down syndrome.Int J Pediatr Otorhinolaryngol. 2018;110:1-5.
20. Dudoignon B, Amaddeo A, Frapin A, et al. Obstructive sleep apnea in Down syndrome: Benefits of surgery and noninvasive respiratory support.Am J Med Genet A. 2017;173(8):2074-2080.
21. Farhood Z, Isley JW, Ong AA, et al. Adenotonsillectomy outcomes in patients with Down syndrome and obstructive sleep apnea.Laryngoscope. 2017;127(6):1465-1470.
22. da Rocha M, Ferraz RCM, Guo Chen V, Antonio Moreira G, Raimundo Fujita R. Clinical variables determining the success of adenotonsillectomy in children with Down syndrome. Int J Pediatr Otorhinolaryngol. 2017;102:148-153.
23. Trucco F, Chatwin M, Semple T, Rosenthal M, Bush A, Tan HL. Sleep disordered breathing and ventilatory support in children with Down syndrome. Pediatr Pulmonol. 2018;53(10):1414-1421.
24. Simpson R, Oyekan AA, Ehsan Z, Ingram DG. Obstructive sleep apnea in patients with Down syndrome: current perspectives. Nat Sci Sleep.2018;10:287-293.
25. Trois MS, Capone GT, Lutz JA, et al. Obstructive sleep apnea in adults with Down syndrome. J Clin Sleep Med. 2009;5(4):317-323.
26. Hawkins A, Langton-Hewer S, Henderson J, Tulloh RM. Management of pulmonary hypertension in Down syndrome. Eur J Pediatr.2011;170(7):915-921.
27. Maris M, Verhulst S, Wojciechowski M, Van de Heyning P, Boudewyns A. Sleep problems and obstructive sleep apnea in children with down syndrome, an overwiew. Int J Pediatr Otorhinolaryngol.2016;82:12-15.
28. Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine.J Clin Sleep Med. 2012;8(5):597-619.
29. Berry RB, Gamaldo CE, Harding SM, et al. AASM Scoring Manual Version 2.2 Updates: New Chapters for Scoring Infant Sleep Staging and Home Sleep Apnea Testing. J Clin Sleep Med. 2015;11(11):1253-1254.
30. Farrell L, Cox DW. Outpatient initiation of non-invasive ventilation in children. Pediatr Pulmonol. 2019;54(1):10.
31. Brooks LJ, Olsen MN, Bacevice AM, Beebe A, Konstantinopoulou S, Taylor HG. Relationship between sleep, sleep apnea, and neuropsychological function in children with Down syndrome. Sleep Breath. 2015;19(1):197-204.
32. Mansell SK, Cutts S, Hackney I, et al. Using domiciliary non-invasive ventilator data downloads to inform clinical decision-making to optimise ventilation delivery and patient compliance.BMJ Open Respir Res. 2018;5(1):e000238.
33. Zhu K, Rabec C, Gonzalez-Bermejo J, et al. Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study. BMC Pulm Med.2017;17(1):145.
34. Piper AJ. Advances in non-invasive positive airway pressure technology. Respirology. 2019.
35. Maris M, Verhulst S, Wojciechowski M, Van de Heyning P, Boudewyns A. Outcome of adenotonsillectomy in children with Down syndrome and obstructive sleep apnoea. Arch Dis Child. 2017;102(4):331-336.
36. Sanders E, Hill CM, Evans HJ, Tuffrey C. The Development of a Screening Questionnaire for Obstructive Sleep Apnea in Children with Down Syndrome. Front Psychiatry. 2015;6:147.
37. Lagan N, Huggard D, Mc Grane F, et al. Multiorgan involvement and management in children with Down Syndrome. Acta Paediatr. 2020.
38. Bull MJ, Committee on G. Health supervision for children with Down syndrome. Pediatrics. 2011;128(2):393-406.
39. Wray J, Waters S, Radley-Smith R, Sensky T. Adherence in adolescents and young adults following heart or heart-lung transplantation.Pediatr Transplant. 2006;10(6):694-700.
40. Menahem S, Halasz G. Parental non-compliance–a paediatric dilemma. A medical and psychodynamic perspective. Child Care Health Dev. 2000;26(1):61-72.
41. Santer M, Ring N, Yardley L, Geraghty AW, Wyke S. Treatment non-adherence in pediatric long-term medical conditions: systematic review and synthesis of qualitative studies of caregivers’ views.BMC Pediatr. 2014;14:63.
42. Killian MO, Schuman DL, Mayersohn GS, Triplett KN. Psychosocial predictors of medication non-adherence in pediatric organ transplantation: A systematic review. Pediatr Transplant.2018;22(4):e13188.
43. Machaalani R, Evans CA, Waters KA. Objective adherence to positive airway pressure therapy in an Australian paediatric cohort. Sleep Breath. 2016;20(4):1327-1336.
44. Shikama M, Nakagami G, Noguchi H, Mori T, Sanada H. Development of Personalized Fitting Device With 3-Dimensional Solution for Prevention of NIV Oronasal Mask-Related Pressure Ulcers. Respir Care.2018;63(8):1024-1032.