2.1 Study Design
A retrospective cohort study was conducted in Children’s Health Ireland,
Crumlin, the largest tertiary paediatric centre in Ireland. Children
with DS aged 0-18 years and a confirmed diagnosis of OSA by
polysomnography (PSG) who were commenced on NIV treatment were included
in the study. Data from non-DS patients on NIV therapy attending our
service were also collected for comparison. This study was approved by
the hospital ethics committee.
Children attending our NIV services were identified via the downloadable
data cloud platform (Fisher & Paykel, Auckland, NZ) data were available
from March 2014 to August 2019. A total of 106 children met inclusion
criteria.