Differences in the distributions of SNP haplotypes
Haplotypes were constructed using SHEsis software in the orderIL2RA rs2104286-rs12722489-rs11594656 and IL 10rs1800896-rs1800871-rs1800872, respectively, and the distributions of the IL2RA and IL-10 haplotypes were compared between the EBV-HLH and control groups. As shown in Table 3, there were no significant differences in IL2RA AGA, GAA, GAT, and GGA between the two groups (P > 0.05); however, the frequencies of AGT and GGT were significantly higher (P = 0.006) and lower (P = 0.001), respectively, in the EBV-HLH group. This suggested that IL2RA AGT was associated with an increased risk of EBV-HLH (OR = 2.102, 95% CI = 1.229–3.593), while GGT significantly reduced the susceptibility to EBV-HLH (OR = 0.364, 95% CI = 0.192–0.689). There was no significant difference in the distribution of IL-10 ATA, GCA, or GCC haplotypes between the two groups (P > 0.05). However, the frequency of IL-10 ACC was significantly higher in the EBV-HLH group (P = 0.003, OR = 2.962, 95% CI = 1.429–6.141), suggesting that this haplotype may be associated with an increased risk of HLH in children with EBV, while the significantly lower frequencies of ACA and GTA (P = 0.020, OR = 0.253, 95% CI = 0.073–0.876; P < 0.05, OR = 0.218, 95% CI = 0.093–0.513, respectively) indicated thatIL-10 ACA and GTA haplotypes may be protective factors for EBV-HLH.