Participants
Twenty-four healthy immunocompetent male and female subjects aged between 18-45 years with Fitzpatrick skin type I-II (Caucasian) and not smoking more than 10 cigarettes per day were included in the study. The ratio male:female was 1:1. Subject health status was verified during a medical screening consisting of a medical history, physical examination, vital signs, 12-lead electrocardiogram, laboratory analysis of blood and urine and a Mantoux and/or interferon gamma release assay. Subjects with a history of tuberculosis were excluded. Routine safety assessments were performed as described earlier (14). Total observation time was 70 days.