Angiotensin-converting
enzyme 2 activator ameliorates severe pulmonary hypertension in a rat
model of left pneumonectomy combined with VEGF inhibition
I-Chen Chen, MD 1,2,3, Jao-Yu Lin, MD4, Yi-Ching Liu, MD 1, Chee-Yin
Chai, MD, PhD 5, Jwu-Lai Yeh, PhD3,6, Jong-Hau Hsu, MD, PhD, 1,2,
Bin-Nan Wu, PhD 3,6 and Zen-Kong Dai, MD, PhD,1,2,3*
1 Department of Pediatrics, Kaohsiung Medical
University Hospital, Kaohsiung, Taiwan
2 Department of Pediatrics, School of Medicine,
College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
3 Graduate Institute of Medicine, College of Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan
4 Department of Surgery, Kaohsiung Medical University,
Kaohsiung, Taiwan
5 Department of Pathology, School of Medicine, College
of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
6 Department of Pharmacology, School of Medicine,
College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Correspondence: Zen-Kong Dai
Zen-Kong Dai, MD, PHD
Department of Pediatrics, Kaohsiung Medical University, 100 Shih-Chuan
1st Road, Sun-Ming District, Kaohsiung 807, Taiwan
Tel: 886-7-3121101-6507 E-mail:
zenkong@kmu.edu.tw Fax:
886-7-3208316
Running title: ACE2 activator ameliorates pulmonary artery hypertension