Statistical analysis
The results obtained from ELISA and Western blots were analyzed by densitometry and expressed as means ± standard error of the mean. All data from the four groups were analyzed using one-way analysis of variance (ANOVA) followed by Tukey’s test. Comparison of the beneficial efficacy of DIZE between the early treatment and the late treatment protocols was conducted by two-way ANOVA (n= 6 rats/group). A P value < 0.05 was considered statistically significant.