2.3 │ Determination of histone H1 subtypes interacting proteins function
Functions assigned to the partnering proteins of histone H1 subtypes were provided by SIFTER (Statistical Interference of Function Through Evolutionary Relationships). This is a statistical approach for prediction protein function with the use of a protein family’s phylogenetic tree as the natural structure for representing protein relationships. Protein function is defined with the confidence score, a value between 0 and 1, calculated based on the number of candidate functions and family size as well as the frequency and distribution of candidate terms in the tree. 14