5 │ CONCLUSIONS
The properties of histone H1 subtypes presented in this study allow to
define them as multifunctional proteins that serve as an elements
coordinating a plethora roles of the cell. Through the interactions with
diversely active proteins, histone H1 subtypes build the complex
networks orchestrated crucial cellular processes including cell cycle,
ribosome biogenesis, translation and degradation of proteins. The
individual and/or common (partially redundant) activity of histone H1
subtypes is realized by forming transient protein complexes through the
disordered regions. Ultimately, the gathered evidences of multifaceted
histone H1 subtypes functioning realized together with partnering
proteins confirms a legitimacy of introducing an extended histone H1
paradigm relating to its operation through the protein-protein
interactions. 8
ORCID Andrzej Kowalski https:/ /orcid.org/0000-0001-8856-5863