2.6 │ Prediction of histone H1 subtypes and interacting proteins
residues contact and binding sites
Binding sites in the protein sequences were predicted with BIPSPI
(xgBoost based Interface Prediction of Specific Partner Interactions), a
partner-specific predictor of residue–residue contacts and protein
binding sites. BIPSPI is a machine learning-based method employs Extreme
Gradient Boosting (XGBoost) models trained on the input sequences pairs
of the protein complexes. 21