2.3 │ Determination of histone H1 subtypes interacting proteins
function
Functions assigned to the partnering proteins of histone H1 subtypes
were provided by SIFTER (Statistical Interference of Function Through
Evolutionary Relationships). This is a statistical approach for
prediction protein function with the use of a protein family’s
phylogenetic tree as the natural structure for representing protein
relationships. Protein function is defined with the confidence score, a
value between 0 and 1, calculated based on the number of candidate
functions and family size as well as the frequency and distribution of
candidate terms in the tree. 14