5 │ CONCLUSIONS
The properties of histone H1 subtypes presented in this study allow to define them as multifunctional proteins that serve as an elements coordinating a plethora roles of the cell. Through the interactions with diversely active proteins, histone H1 subtypes build the complex networks orchestrated crucial cellular processes including cell cycle, ribosome biogenesis, translation and degradation of proteins. The individual and/or common (partially redundant) activity of histone H1 subtypes is realized by forming transient protein complexes through the disordered regions. Ultimately, the gathered evidences of multifaceted histone H1 subtypes functioning realized together with partnering proteins confirms a legitimacy of introducing an extended histone H1 paradigm relating to its operation through the protein-protein interactions. 8
ORCID Andrzej Kowalski https:/ /orcid.org/0000-0001-8856-5863