2.6 │ Prediction of histone H1 subtypes and interacting proteins residues contact and binding sites
Binding sites in the protein sequences were predicted with BIPSPI (xgBoost based Interface Prediction of Specific Partner Interactions), a partner-specific predictor of residue–residue contacts and protein binding sites. BIPSPI is a machine learning-based method employs Extreme Gradient Boosting (XGBoost) models trained on the input sequences pairs of the protein complexes. 21