Study population and clinical information
We retrospectively surveyed all neonates born to mothers with COVID-19 from January 31 to March 31 2020, and investigated 11 neonates with confirmed SARS-CoV-2 infection in COVID-19 group, and 11 normal neonates in control group.
All the clinical materials and lung ultrasound images were analyzed in both groups. This study was approved by the local medical ethics committee. Written informed consent was obtained from the neonates’ parents. The diagnosis and management of neonate with or at risk of COVID-19 were in accordance with guidelines provided by the National Health Commission and the Chinese Perinatal-Neonatal SARS-CoV-2 Committee3.
Data were collected from. regarding demographic, epidemiologic, and clinical features were obtained from the medical records system. In addition, SARS-CoV-2 real- time RT-PCR tests (Novel Coronavirus PCR Fluorescence Diagnostic Kit, Da An Gene, Guangdong, P. R. China) were conducted using nasopharyngeal swab samples. SARS-CoV-2 specific serum IgM and IgG test were performed. All the neonates underwent influenzas virus screening and tested negatives.
The inclusive criteria were: neonates born to mothers with COVID-19; positive results in SARS-CoV-2 real-time RT-PCR tests using nasopharyngeal swabs or positive results in SARS-CoV-2 specific IgM using serum. The exclusive criteria were other etiological neonatal pneumonia, combined with other congenital abnormalities.