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\begin{document}

\title{Omalizumab in children and adolescents with chronic urticaria: A 16 week
real-world study}



\author[1]{Xiaoting Song}%
\author[1]{Yu-di Chen}%
\author[2]{Miao Yu}%
\author[1]{Bo Liu}%
\author[3]{Zuotao Zhao}%
\author[4,5]{Marcus Maurer}%
\affil[1]{Peking University First Hospital}%
\affil[2]{Peking University School of Nursing}%
\affil[3]{First Hospital, Peking University}%
\affil[4]{Wiley}%
\affil[5]{Charité Universitätsmedizin Berlin}%


\vspace{-1em}



  
  \date{May 07, 2024}


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\begin{abstract}
Background: The efficacy and safety of omalizumab in adult patients with
refractory chronic urticaria (CU) is well established, but there is
little information on the treatment of children. Here, we assessed the
efficacy, time to onset of effects, improvement of quality of life, and
safety of omalizumab in children and adolescents with CU. Methods:
Patients aged \textless{} 18 years with antihistamine-resistant CU were
treated with 150 or 300 mg of omalizumab every four weeks. We used the
recently validated Chinese version of urticaria control test (UCT) to
assess disease control status, children's dermatology life quality index
(CDLQI) to evaluate quality of life impairment, and monitored adverse
events to assess the safety. Results: We treated 12 CU patients (7
female, mean age 10.2 \selectlanguage{ngerman}± 4.4 years, range 3--16) with omalizumab. Two
thirds (67\%) of the patients achieved well-controlled CU (defined as a
UCT score \selectlanguage{english}[?] 12) after the first administration. The UCT score
significantly increased from 2.5 (0.0-5.8) at baseline to 12.0
(1.3-13.8) after four weeks (Z=-3.063, P=0.002) and 15.0 (13.5-16.0)
after 16 weeks (Z=-3.065, P=0.002). The CDLQI score decreased from 17.5
(14.5-20.5) at baseline to 9.0 (3.0-13.8) after four weeks (Z=-2.984,
P=0.003) and 2.0 (0.0-6.8) after 16 weeks (Z=-3.063, P=0.002). No
adverse events were observed. Conclusion: Omalizumab is effective, fast
acting and safe for children and adolescents with
antihistamine-resistant chronic urticaria.%
\end{abstract}\selectlanguage{ngerman}%



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\textbf{Hosted file}

\verb`Omalizumab in children and adolescents with chronic urticaria final.docx`  available at \url{https://authorea.com/users/360756/articles/482289-omalizumab-in-children-and-adolescents-with-chronic-urticaria-a-16-week-real-world-study}

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