The epicardial region of LVS is covered by the fibers of the intrinsic cardiac nervous autonomic system [52–54], gathering nearly 6% of all ganglionated plexuses of the heart [20,55]. These plexuses are embedded in the epicardial adipose tissue. The first portion of the left coronary ganglionated subplexus with preganglionated nerves is densely distributed nearby the pulmonary trunk and ascending aorta in septal summit region. Postganglionated nerves extend into anterior, lateral and (in part) posterior walls of the left ventricle. Moreover, thin short postganglionated nerves proceed on the interior surface of the left atrial appendage along the atrial branches of the circumflex branch of the left coronary artery [20]. The subendocardially located Purkinje network that originates from the left bundle branch’s anterior division most likely activates the LVS region. The anterior division of the left bundle branch proceeds toward the base of the superolateral papillary muscle of the mitral valve. It is formed of many fine strands coursing anteriorly to the free wall [56–58]; thus, this segment is most likely to support the LVS region. However, both networks from anterior and posterior divisions of the left bundle branch are widely interconnected [59,60]. Another argument for anterior division distribution in the LVS region is the possibility of mapping and ablating the left anterior fascicle from the right aortic sinus [61].