Figure 2. Effect of PTPRT D1364Gfs*24 on the protein structure.
(A) Schematic representation of PTPRT protein domains, with the location of the studied mutation and the resulting mutant protein (below). B) 3D representation of the cytoplasmatic region of wild-type (left) and mutant (right) PTPRT, showing the effect of the truncation. 3D models were obtained by SWISS-MODEL. C) Amino acid sequence of PTPRT’s D2 domain with the effect produced by the mutation. Those residues directly surrounding the pTyr are marked in grey. Underlined are all the residues that differ between the two forms of PTPRT. Modified from Lui et al. 2013.