Figure 2. Effect of PTPRT D1364Gfs*24 on the protein
structure.
(A) Schematic representation of PTPRT protein domains, with the location
of the studied mutation and the resulting mutant protein (below). B) 3D
representation of the cytoplasmatic region of wild-type (left) and
mutant (right) PTPRT, showing the effect of the truncation. 3D models
were obtained by SWISS-MODEL. C) Amino acid sequence of PTPRT’s D2
domain with the effect produced by the mutation. Those residues directly
surrounding the pTyr are marked in grey. Underlined are all the residues
that differ between the two forms of PTPRT. Modified from Lui et al.
2013.