Fig. 1. Circulatory CD27+IgD+B cell
amounts are reduced in SLE cases in comparison with healthy control (HC)
patients. (A) Gating strategy for identifying naïve
(CD27-IgD+), innate-like
(CD27+IgD+), switched memory
(CD27+IgD-) and double negative
(CD27-IgD-) B cells in human blood.
(B) CD27+IgD+B cells obtained from
representative HC (left panel) and SLE (right panel) patients. (C)
Percentages of CD27+IgD+ B cells in
SLE (n=50) and HC (n=50) patients.
Data are mean±SD or median and interquartile range. Data points
represent individual participants. NS, not significant.
**p<0.01, ***p<0.001