Introduction
Globally, the overwhelming majority of nasopharyngeal carcinomas (NPC) occur within endemic or migrant south East Asian populations driven by exposure to the Epstein-Barr virus (EBV). However, human papillomavirus (HPV) associated NPC has also been described, mostly in Caucasian populations. Co-infections with both EBV and HPV has been rarely reported and similar to oropharyngeal cancer (OPC), p16 shows high sensitivity and specificity for HPV associated NPC (1).
There are few reports of synchronous or metachronous p16+/HPV+ cancers where the nasopharynx is primarily involved (excluding those with extension from the oropharynx). Caley et al. reported 11 cases of synchronous and metachronous p16+ head and neck squamous cell carcinoma (SCC), which included two cases involving metachronous nasopharynx and OPC (2). McGovern el al described an interesting report of synchronous HPV-associated SCC involving the bilateral tonsils and nasopharynx treated with radical intent radiotherapy and concurrent chemotherapy(3).
We report a case of a patient presenting with synchronous p16+ SCC involving the nasopharynx and BOT treated at our institution