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\begin{document}

\title{ALGORITHMS FOR TESTING COVID-19 FOCUSED ON USE OF RT-PCR AND
HIGH-AFFINITY SEROLOGICAL TESTING: a consensus statement from a panel of
Latin American experts}



\author[1]{Antonio Condino-Neto}%
\author[1]{Pablo E Bonvehi}%
\author[1]{Juan Carlos Gómes de La Torre}%
\author[1]{Klever Vinicio Sáenz-Flor}%
\author[1]{Carlos Eduardo dos Santos Ferreira}%
\affil[1]{Affiliation not available}%


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  \date{May 05, 2024}


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\begin{abstract}
The COVID-19 pandemic has caused an unprecedented public health, social,
and economic crisis. Improving understanding on available tests for
detecting COVID-19 is critical for effective management of the pandemic.
We proposed that a multidisciplinary expert panel can establish
recommendations on ideal use of diagnostic tools, with a focus on RT-PCR
and serological high-affinity antibodies (both IgM and IgG) tests for
the Latin America region. STUDY DESIGN: A collaborative
multidisciplinary panel of 5 recognized experts in Latin America (an
infectious disease specialist, three pathologists and an immunologist)
was convened and supported by Roche Diagnostics to develop standard
guidelines and an evidence-based document of best practices on the use
of diagnostic tools for COVID-19. RESULTS: The authors reached consensus
on the applicability of diagnostic tools to provide testing algorithms
for the use of RT-PCR and serological high-affinity antibodies (both IgM
and IgG) tests in three settings: 1) For asymptomatic subjects exposed
to a SARS-CoV-2 infected person; 2) For epidemiological purposes and; 3)
For symptomatic subjects. CONCLUSION: The serological high-affinity
SARS-Cov-2 antibodies (both IgM and IgG) tests play a key role in
COVID-19 diagnosis. These tests can be applied for suspected
false-negative RT-PCR results and for individual determination of
response. The use of these tests can also contribute greatly to public
health strategies, such as population screening and supporting
vaccination planning. Serological status for high-affinity antibodies
(both IgM and IgG) should be performed ideally 21 days after potential
infectious contact, given that the majority of exposed individuals will
have seroconverted.%
\end{abstract}%



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