Individual Variability
Urine specimens were classified into urotypes, defined by the predominant (>50% abundance) genus present.2 If no genus reached 50% abundance, the urotype was classified as ‘divese’. And a total of 27 urine specimens had matching urotypes, while all other samples were diverse. The most frequent urotype in both cohorts was Lactobacillus(M group 29.4%, M/S group 22.6%). Two urotypes were present in both cohorts (Lactobacillus and Streptococcus ). TheHaemophilus , Escherichia-Shigella , Enterococcus andSneathia urotypes were present only in the mild cohort, whereas the Gardnerella urotype was present only in the moderate/severe cohort; however, these differences were not statistically significant at our current sample size. The number of different bacterial genera in each individual’s urinary microbiome ranged from 24 to 117 (mild range 24–86 genera per sample, moderate/severe range 30–117 genera per sample).