CONCLUSION
In conclusion, findings in our study suggest that bladder microbiome is related to LUTS severity. The results of our research offer strong evidence that the higher bacterial diversity and richness was associated with worse OAB symptom severity, and several specific bacterial genera relate to sub-symptoms of OAB respectively, suggest that specific urinary dysbiosis may constitute an etiological factor in exacerbating functional bladder disorders, with potential diagnostic and therapeutic implications in the near future.
Disclosure: Nothing to disclose.
Funding: Supported by the National Natural Science Foundation of China (Grant No. 81870522).
Contribution to authorship: Conceptualization, Kun Li, Chunxiao Chen, Jie Zhao and Peng Wu; Patient recruitment, Specimens and demographic information collection, Kun Li, Chunxiao Chen, Jiarong Zeng, Yuehui Wen, Biao Li and Weihong Chen; Specimen processing and data analysis Jie Zhao and Peng Wu; Writing – original draft, Kun Li, Chunxiao Chen; Writing – review & editing, Kun Li, Chunxiao Chen, Jie Zhao and Peng Wu.