CONCLUSION
In
conclusion, findings in our study suggest that bladder microbiome is
related to LUTS
severity.
The results of our research offer strong evidence that the higher
bacterial diversity and richness was associated with worse OAB symptom
severity, and several specific bacterial genera relate to sub-symptoms
of OAB respectively, suggest that specific urinary dysbiosis may
constitute an etiological factor in exacerbating functional bladder
disorders, with potential diagnostic and therapeutic implications in the
near future.
Disclosure: Nothing to disclose.
Funding: Supported by the National Natural Science Foundation
of China (Grant No. 81870522).
Contribution to authorship: Conceptualization, Kun Li, Chunxiao
Chen, Jie Zhao and Peng Wu; Patient recruitment, Specimens and
demographic information collection, Kun Li, Chunxiao Chen, Jiarong Zeng,
Yuehui Wen, Biao Li and Weihong Chen; Specimen processing and data
analysis Jie Zhao and Peng Wu; Writing – original draft, Kun Li,
Chunxiao Chen; Writing – review & editing, Kun Li, Chunxiao Chen, Jie
Zhao and Peng Wu.