References
Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I (2010). SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun 393: 66-72.
Austin V, Crack PJ, Bozinovski S, Miller AA, Vlahos R (2016). COPD and stroke: are systemic inflammation and oxidative stress the missing links? Clin Sci (London, England : 1979) 130: 1039-1050.
Azad GK, Tomar RS (2014). Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways. Mol Biol Rep 41: 4865-4879.
Barnes PJ, Celli BR (2009). Systemic manifestations and comorbidities of COPD. Eur Respir J 33: 1165-1185.
Bartalis J, Chan WG, Wooten JBJAc (2007). A new look at radicals in cigarette smoke. Anal Chem 79: 5103-5106.
Bernardo I, Bozinovski S, Vlahos R (2015). Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities. Pharmacol Ther 155: 60-79.
Brassington K, Selemidis S, Bozinovski S, Vlahos R (2019). New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease. Clin Sci (London, England: 1979) 133: 885-904.
Chan CK, Vanhoutte PMJAPSB (2013). Hypoxia, vascular smooth muscles and endothelium. Acta Pharm Sin B 3: 1-7.
Chan SM, Cerni C, Passey S, Seow HJ, Bernardo I, van der Poel C, et al. (2020). Cigarette smoking exacerbates skeletal muscle injury without compromising its regenerative capacity. Am J Respir Cell Mol Biol 62(2):217-230.
Chew P, Yuen DYC, Stefanovic N, Pete J, Coughlan MT, Jandeleit-Dahm KA, et al. (2010). Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. Diabetes 59: 3198-3207.
Crack PJ, Taylor JM, Flentjar NJ, De Haan J, Hertzog P, Iannello RC, et al. (2001). Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem 78:1389-1399.
de Haan JB, Cooper ME (2011). Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction. Front Biosci (Scholar edition) 3: 709-729.
Duong C, Seow HJ, Bozinovski S, Crack PJ, Anderson GP, Vlahos R (2010). Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol 299:L425-433.
Edirisinghe I, Rahman I (2010). Cigarette smoke–mediated oxidative stress, shear stress, and endothelial dysfunction: role of VEGFR2. Ann N Y Acad Sci 1203: 66-72.
Endemann DH, Schiffrin EL (2004). Endothelial dysfunction. J Am Soc Nephrol 15: 1983-1992.
Geraghty P, Hardigan AA, Wallace AM, Mirochnitchenko O, Thankachen J, Arellanos L, et al. (2013). The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction. Am J Respir Cell Mol Biol 49: 721-730.
Hansen MJ, Chen H, Jones JE, Langenbach SY, Vlahos R, Gualano RC, et al. (2013). The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice. PLoS One 8: e80471.
James AL, Wenzel S (2007). Clinical relevance of airway remodelling in airway diseases. Eur Respir J 30: 134-155.
Kluchova Z, Petrasova D, Joppa P, Dorkova Z, Tkacova R (2007). The association between oxidative stress and obstructive lung impairment in patients with COPD. Physiol Res 56: 51-56.
Kolluru GK, Bir SC, Kevil CG (2012). Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing. Int J Vasc Med 2012: 918267.
Li H, Forstermann U (2014). Pharmacological prevention of eNOS uncoupling. Curr Pharm Des 20: 3595-3606.
Mukhopadhyay S, Hoidal JR, Mukherjee TK (2006). Role of TNFalpha in pulmonary pathophysiology. Resp Res 7: 125.
Oostwoud LC, Gunasinghe P, Seow HJ, Ye JM, Selemidis S, Bozinovski S, et al. (2016). Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice. Sci Rep 6: 20983.
Pesci A, Balbi B, Majori M, Cacciani G, Bertacco S, Alciato P, et al. (1998). Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J 12: 380-386.
Rask-Madsen C, King GL (2007). Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab 3: 46-56.
Rincon M, Irvin CG (2012). Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci 8: 1281-1290.
Santos M, Oliveira A, Viegas-Crespo A, Vicente L, Barreiros A, Monteiro P, et al. (2004). Systemic markers of the redox balance in chronic obstructive pulmonary disease. Biomarkers 9: 461-469.
Sarker KP, Biswas KK, Rosales JL, Yamaji K, Hashiguchi T, Lee KY, et al. (2003). Ebselen inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38 MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2. J Neurochem 87: 1345-1353.
Sarma BK, Mugesh G (2008). Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates. Chemistry 14: 10603-10614.
Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, et al. (2011). Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 124: 444-453.
Sin DD, Anthonisen NR, Soriano JB, & Agusti AG (2006). Mortality in COPD: Role of comorbidities.Eur Respir J 28: 1245-1257.
Sin DD, Man SF (2005). Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality. Proc Am Thorac Soc 2: 8-11.
Smith SM, Min J, Ganesh T, Diebold B, Kawahara T, Zhu Y, et al.(2012). Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chem Biol 19: 752-763.
Tabit CE, Chung WB, Hamburg NM, Vita JA (2010). Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord 11: 61-74.
Takasago T, Peters EE, Graham DI, Masayasu H, Macrae IM (1997). Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. Br J Pharmacol 122: 1251-1256.
Tkacova R, Kluchova Z, Joppa P, Petrasova D, & Molcanyiova A (2007). Systemic inflammation and systemic oxidative stress in patients with acute exacerbations of COPD. Respir Med 101: 1670-1676.
The Lung Foundation. COPD: The Statistics. Available from http://lungfoundation.com.au/health-professionals/clinical-resources/copd/copd-the-statistics/. [Accessed: 15.3.2017].
To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, et al.(2017). Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy. Nat Commun 8: 69.
Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S (2009). Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care 32 Suppl 2: S314-321.
Vlahos R, Bozinovski S (2014). Recent advances in pre-clinical mouse models of COPD. Clin Sci (London, England : 1979) 126: 253-265.
Vlahos R, Bozinovski S, Chan SPJ, Ivanov S, Lindén A, Hamilton JA, et al. (2010). Neutralizing granulocyte/macrophage colony–stimulating factor inhibits cigarette smoke–induced lung inflammation. Am J Respir Crit Care Med 182: 34-40.
Vlahos R, Bozinovski S, Jones JE, Powell J, Gras J, Lilja A, et al. (2006). Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice. Am J Physiol Lung Cell Mol Physiol 290: L931-945.
Vlahos R, Selemidis S (2014). NADPH oxidases as novel pharmacologic targets against influenza A virus infection. Mol pharmacol 86:747-759.
Vlahos R, Stambas J, Bozinovski S, Broughton BRS, Drummond GR, Selemidis S (2011). Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation. PLoS Pathog 7: e1001271.
The World Health Organisation. The top 10 causes of death.Available from http://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death..
Yatmaz S, Seow H, Gualano R, Wong Z, Stambas J, Selemidis S, et al. (2013). Glutathione Peroxidase-1 Reduces Influenza A Virus–Induced Lung Inflammation. Am J Respir Cell Mol Biol 48: 17-26.
Zhang M, Nomura A, Uchida Y, Iijima H, Sakamoto T, Iishii Y, et al. (2002). Ebselen suppresses late airway responses and airway inflammation in guinea pigs. Free radic biol Med 32: 454-464.
Zhang WZ, Venardos K, Chin-Dusting J, Kaye DM (2006). Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress. Hypertension 48: 278-285.