Monocyte subsets in IgAN
Based on the expression of the cell surface markers CD14 and CD16 we
identified three monocyte subsets: classical monocytes (CD14++, CD16-),
intermediate monocytes (CD14++ CD16+) and non-classical monocytes (CD14+
CD16++). Patients with IgAN had a higher proportion of non-classical
monocytes (CD14+ CD16++) compared to both HC and patients with ADPKD
(p=0.004 and p< 0.001 respectively, Fig. 4). No significant
differences were observed regarding classical monocyte- (CD14++, CD16-)
or intermediate monocyte proportions (CD14++ CD16+) (data not shown).