T-lymphocyte subsets in patients with IgAN, disease controls and
healthy controls
Comparing IgAN patients, ADPKD and HC, no significant differences were
found in proportions of T-lymphocyte subsets; CD4+ naïve cells, CD4+
memory cells, CD8+ naïve cells or CD8+ memory cells (data not shown). No
differences were detected in the fraction of T-helper cell subsets; Th1,
Th2, Th17 as well as regulatory T cells (data not shown).
We also analyzed the ratios between pre-switched B cells and
plasmablasts and Th2, as the cytokines produced by Th2 cells drive the
differentiation and maturation of B cells. The ratios were significantly
lower in IgAN patients compared to HC (p<0.001). The ADPKD
also showed a lower pre-switched B cell/Th2 ratio compared to HC (p=
0.03), though this was not the case regarding plasmablast/Th2 ratio
(data not shown).