Conclusion
Our study found that pediatric HCT survivors surveyed at a median of 27
years post-transplant reported higher frequencies of impairments in the
domains of emotional regulation, task efficiency, memory, and
organization but similar cognitive quality of life compared with the
general population. Subsets of survivors with certain neurologic
co-morbidities were at higher risk for worse neurocognitive outcomes,
which may influence monitoring and counseling for post-HCT survivorship
care. Sleep intervention and early referral for educational and
rehabilitation services may offer possible avenues to mitigate
HCT-related treatment effects on later life achievements.