3.4 Complications and Clinical outcome
Among all studies, total complications related to the LBBAP procedure included 19 cases: 11 cases of reposition to another location in the left bundle branch area due to septal perforation during the procedure, three cases of pneumothorax, three cases of pocket infection requiring incision and drainage, and two cases of pocket hematoma requiring evacuation. During the follow-up period, five cases of lead dislodgements were observed.
One study reported both preimplant and postimplant New York Heart Association (NYHA) functional classes before and after LBBAP in patients with HFmrEF. In that study, during a mean follow-up of 10.4 months, NYHA functional status in patients with HFmrEF who underwent LBBAP improved from 2.5 ± 0.5 at baseline, to 1.7 ± 0.8 at follow-up (P<0.01). One study reported hospitalization for HF after LBBAP in patients with HFmrEF; in this study, the HF hospitalization rate was 17.6% during a mean follow-up of 6.0 months after LBBAP.