3.4 Complications and Clinical outcome
Among all studies, total complications related to the LBBAP procedure
included 19 cases: 11 cases of reposition to another location in the
left bundle branch area due to septal perforation during the procedure,
three cases of pneumothorax, three cases of pocket infection requiring
incision and drainage, and two cases of pocket hematoma requiring
evacuation. During the follow-up period, five cases of lead
dislodgements were observed.
One study reported both preimplant and postimplant New York Heart
Association (NYHA) functional classes before and after LBBAP in patients
with HFmrEF. In that study, during a mean follow-up of 10.4 months, NYHA
functional status in patients with HFmrEF who underwent LBBAP improved
from 2.5 ± 0.5 at baseline, to 1.7 ± 0.8 at follow-up
(P<0.01). One study reported hospitalization for HF after
LBBAP in patients with HFmrEF; in this study, the HF hospitalization
rate was 17.6% during a mean follow-up of 6.0 months after LBBAP.