GDM and children allergen sensitization
One study was included in subgroup analysis, with a pooled effect estimate of 1.45 (95%CI:0.40, 5.23). In this study, the sensitization outcomes included food sensitization, aeroallergen sensitization and total sensitization (22). Allergen sensitization was defined as specific IgE>0.10 kUA/L resulting from at least one of the tested allergens, including food (egg white, milk, peanut, soy, shrimp, wheat, and walnut) and aeroallergens (dermatophygoides pteronyssinus and dermatophygoides farinae, German cockroach, cat, dog, and Alternaria alternata). Similar criterion was used in other studies (23, 24). Due to the heterogeneity of the studies (I2 =70.5%, P=0.005), a random effect model was used to show the relationship between gestational diabetes and sensitization. (Figure 3(d) )