Study search and characteristics overview
We retrieved 2153 articles published before December 31, 2019 about the
outcome of asthma from PubMed (613 articles), Web of Science (548
articles) and Cochrane Library (992 articles). Duplicated articles were
removed automatically (n=358). After reviewing titles and abstracts from
1795 articles, 1782 studies were excluded, including 575 reviews,
lecture materials, and randomized controlled study; 115 animal studies;
1021 studies unrelated to our research objective; 44 molecular mechanism
studies; 25 articles duplicates excluded manually and 2 non-English
studies. Of the remaining 13 full-text publications, five were further
excluded due to various reasons, only abstract, incomplete statistics
and irrelevant exposure. Finally, eight articles were included in this
meta-analysis. (Figure 1)
We retrieved 1431 articles published before December 31, 2019 about the
outcome of atopic dermatitis from PubMed (723 articles), Web of Science
(240 articles), and Cochrane Library (468 articles). Duplicated articles
were removed automatically (n=133). After reviewing the titles and
abstracts of 1,298 articles, 1,291 studies were excluded, including 453
reviews, presentation materials and randomized controlled studies;106
animal studies; 707 studies unrelated to our research objective; 11
molecular mechanism studies; 13 repeated studies, and 1 non-English
study. Of the \soutleft remaining seven full-text articles, one
written in an abstract was excluded. In the end, six studies were
included for analysis. (Figure 1)
We retrieved 1,374 articles published before December 31, 2019 on the
outcome of food allergy from PubMed (697 articles), Web of Science (223
articles) and Cochrane Library (454 articles). Duplicated articles were
automatically removed (n = 123). After reviewing the titles and
abstracts of 1251 articles, 1243 studies were excluded, including 426
reviews, lecture materials and randomized controlled studies; 102 animal
studies; 690 items unrelated to the research objective; 16 molecular
mechanism studies; 9 repeated studies. Of the remaining eight full-text
publications, one abstract was excluded. Finally, seven articles were
included .(Figure 1)
To sum up, a total of eight articles were included. (Table 1)Several of
them provided multiple sets of outcomes, with different effect estimates
and 95% confidence intervals. Six studies were cohort studies; two were
case-control studies. All studies were human population based. In the
two case-control studies, the size of case groups ranged from 916 to
14,803, and the size of control groups ranged from 16,527 to 1,386,029;
and the size of cohort studies ranged from 131 to 965,224.