3.3 I Dry eyes
Three patients developed dry eyes after receiving CSI (Table 2). One patient had severe dry eyes requiring cyclosporine ophthalmic suspension towards the end of radiation, with subsequent resolution during follow-up. The second patient had moderate dry eyes requiring artificial tears 2 weeks after finishing radiation, and the last patient developed mild dry eyes ~8 months post-radiation but did not need any treatment.
Amongst these 3 patients, there was no correlation of severity of dry eyes and the radiation dose to the lenses, lacrimal glands, and cornea, as the patient with mild dry eyes received higher doses to these structures. However, all 3 patients did receive significant radiation to these ocular components, with the median of the average (right and left eyes) dose to the lenses, lacrimal glands and corneas being 27.93 (11.98 – 28.71), 36.96 (25.12 – 47.49) and 30.78 (25.08 – 36.49) Gy RBE, respectively.