3.3 I Dry eyes
Three patients developed dry eyes after receiving CSI (Table 2). One
patient had severe dry eyes requiring cyclosporine ophthalmic suspension
towards the end of radiation, with subsequent resolution during
follow-up. The second patient had moderate dry eyes requiring artificial
tears 2 weeks after finishing radiation, and the last patient developed
mild dry eyes ~8 months post-radiation but did not need
any treatment.
Amongst these 3 patients, there was no correlation of severity of dry
eyes and the radiation dose to the lenses, lacrimal glands, and cornea,
as the patient with mild dry eyes received higher doses to these
structures. However, all 3 patients did receive significant radiation to
these ocular components, with the median of the average (right and left
eyes) dose to the lenses, lacrimal glands and corneas being 27.93 (11.98
– 28.71), 36.96 (25.12 – 47.49) and 30.78 (25.08 – 36.49) Gy RBE,
respectively.