\(\max f_{1}=\max\left({\dot{n}}_{CCI,out}\right)=\max{f(v_{eff,ADH},v_{\text{FDH}},v_{\text{Lipase}})}\) (14)
\(\min f_{2}=\min{\left(n_{Co-factor}\right)=\min{f(c_{\text{NAD}^{+}}},\ c_{\text{NADH}},\ V})\) (15)
\(0\leq c_{i}\leq c_{\text{solubility}}\) (16)