3.1 | Study population
The characteristics and laboratory data for the AD patients and HCs are
shown in Table S1. The number of AD patients was 38 and the median age
was 45.5 (20–63) years. The male-to-female ratio was 25 (65.8%) to 13
(34.2%). Disease duration was 36.0 (6–57) years. Median EASI score was
18.5 (1.0–54.3). Median total serum IgE was 6336.3 IU/mL. Complications
with other allergic diseases were allergic rhinitis in 17 (45.0%),
asthma in 16 (42.1%), food allergy in 11 (29.0%), allergic
conjunctivitis in 7 (18%), and urticaria in 6 (15.8%). The number of
HCs was 21 and the median age was 29.0 (26–46) years. The
male-to-female ratio was 7 (33.3%) to 14 (66.7%).
3.2 | Analysis of
c linical and laboratory
factors in AD patients
Clinical factors, disease severity reflected by EASI
scores,35 and laboratory factors including thymus and
activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), and
total serum IgE were analyzed in AD patients.36 Among
the AD patients, moderate positive correlations were observed between
EASI score and TARC (rs = .50) and between EASI score
and LDH (rs = .67) (Figure 1 A, B). Although not
statistically significant, there was a mild positive correlation between
EASI score and total serum IgE (rs = .31) (Figure 1 C).