Inhibitory effect of THB fraction on sPLA2 activity of serum
from dengue patients
We previously showed that patients with dengue had high levels of sPLA2
activity during the febrile phase of dengue infection and therefore,
serum samples were obtained from patients (n=31) with a duration of
symptoms of ≤ 4 days 9. The inhibitory effect of THB
was assessed at concentrations of 0.1 µg/µL and
0.2 µg/µL on dengue patient sera.
Both concentrations of THB significantly reduced the sPLA2 acitivity
(p<0.0001) in the sera of dengue patients (Figure 1). The
inhibition of sPLA2 acitivity of both concentrations of THB was
significantly lower (p<0.0001) than the inhibition observed
with the commercial sPLA2 inhibitor, CAY10590 (Figure 1).