Inhibitory effect of THB fraction on sPLA2 activity of serum from dengue patients
We previously showed that patients with dengue had high levels of sPLA2 activity during the febrile phase of dengue infection and therefore, serum samples were obtained from patients (n=31) with a duration of symptoms of ≤ 4 days 9. The inhibitory effect of THB was assessed at concentrations of 0.1 µg/µL and 0.2 µg/µL on dengue patient sera. Both concentrations of THB significantly reduced the sPLA2 acitivity (p<0.0001) in the sera of dengue patients (Figure 1). The inhibition of sPLA2 acitivity of both concentrations of THB was significantly lower (p<0.0001) than the inhibition observed with the commercial sPLA2 inhibitor, CAY10590 (Figure 1).