‘What this study adds’
- Inactivation of SERCA2 Cys674 causes the imbalance
between PPARγ and NFAT/NF-κB in SMCs, leads to the sustained
activation of NFAT/NF-κB.
- Activation of PPARγ could restore this balance, thus suppresses SMC
phenotypic modulation and aortic aneurysm formation caused by the
inactivation of SERCA2 Cys674.