Figure 3. KS conformational change enables approach of the acyl-ACP and reactive cysteine. a) A schematic shows the contacts made in the top solution for PikMod6. b) A stereodiagram compares AlphaFold-Multimer solutions in which PikACP6 docks with PikKS6 with its TxLGDP motif in the α-conformation (gray) or the β-conformation (green and cyan). c) A stereodiagram shows the solution with the β-conformation with an acetyl-phosphopantetheinyl arm modeled between the conserved ACP serine and the KS reactive cysteine (both labeled *).