Introduction
Whole genome sequencing (WGS) has been essential to clarify a key aspect
in the COVID-19 pandemic, namely, the analysis of recurrences, allowing
to identify which are due to reinfections
(Mulder et al., 2020;
Tillett et al., 2020). Genomic research
has demonstrated the prolonged persistence of viable SARS-CoV-2 in
severely immunosuppressed patients (Baang
et al., 2020; Choi et al., 2020), but it
has not equally been used to support reactivations, and the scarce
reports focus primarily on clinical descriptions
(Coppola, Annunziata, Carannante, Di
Spirito, & Fiorentino, 2020). Furthermore, the potential relationship
between SARS-CoV-2 reactivation and associated nosocomial outbreaks has
not been described to date. In this study we present a SARS-CoV-2
reactivation and its consequences in the nosocomial setting.