Outcomes ACEIs/ARBs p-value ACEIs p-value ARBs P-value
Death 0.973 (0.746, 1.269) 0.84 1.049 (0.751, 1.464) 0.781 1.181 (0.983, 1.418) 0.076
Number of studies 11 2 2
I-squared 65.5% 0.001 26.3% 0.244 0.6% 0.316
ICU 1.086 (0.652, 1.809) 0.75 0.945 (0.65, 1.376) 0.769 1.49 (1.126, 1.973) 0.005
Number of studies 6 3 3
I-squared (p-value) 84.4% <0.001 4.9% 0.349 0% 0.475
Death/ICU 0.67 (0.524, 0.857) 0.001 0.888 (0.694, 1.136) 0.345 0.83 (0.65, 1.061) 0.136
Number of studies 3 2 2
I-squared (p-value) 0% 0.572 0% 0.726 0% 1.000
Risk of COVID-19 1.014 (0.935, 1.099) 0.745 1.133 (1.417, 21.27) 0.273 0.557 (0.107, 2.895) 0.46
Number of studies 7 3 2
I-squared (p-value) 0% 0.75 0% 0.457 97.9% <0.001
Severe COVID-19 0.782 (0.529, 1.154) 0.215 0.718 (0.264, 1.955) 0.517 0.506 (0.247, 1.036) 0.062
Number of studies 6 3 3
I-squared (p-value) 43.3% 0.117 0% 0.799 18% 0.296
Severe pneumonia 1.285 (0.237, 6.958) 0.771 NA NA
Number of studies 2
I-squared (p-value) 57.5% 0.125
Hospitalisation 1.153 (0.806, 1.65) 0.436 1.077 (0.791, 1.465) 0.638 0.907 (0.74, 1.112) 0.349
Number of studies 5 5 5
I-squared (p-value) 74.5% 0.003 63.7% 0.026 0% 0.965
Hospital discharge 1.213 (0.739, 1.991) 0.446 NA NA
Number of studies 3
I-squared (p-value) 82.2% 0.004
Ventilator use 1.492 (0.804, 2.77) 0.205 1.014 (0.03, 34.758) 0.994 0.985 (0.084, 11.57) 0.990
Number of studies 4 2 2
I-squared (p-value) 80.7% 0.001 64.7% 0.092 88.6% 0.003
ICU/ventilator use 1.225 (0.836, 1.795) 0.298 1.149 (0.554, 2.382) 0.709 1.467 (0.907, 2.373) 0.118
Number of studies 10 5 5
I-squared (p-value) 83.2% <0.001 75.2% 0.003 66.2% <0.001
(Note) NA: not applicable indicating no enough studies to perform meta-analyses (Note) NA: not applicable indicating no enough studies to perform meta-analyses (Note) NA: not applicable indicating no enough studies to perform meta-analyses (Note) NA: not applicable indicating no enough studies to perform meta-analyses (Note) NA: not applicable indicating no enough studies to perform meta-analyses (Note) NA: not applicable indicating no enough studies to perform meta-analyses (Note) NA: not applicable indicating no enough studies to perform meta-analyses