Conclusion
Thus, our proposals for nomenclature and classification of allergy include the following points:
1. Pathologically altered body reactivity can be of two types: increased, hyperreactive – allergy, and reduced – anergy.
2. Allergy includes two reaction stages: 1) hypersensitivity (without clinical manifestations) and 2) hyperreactivity with clinical symptoms.
3. A specific immunologically mediated allergy depends on the presence of antibodies of different isotypes and immune T and B lymphocytes to the allergen.
4. Nonspecific allergy is hypersensitivity and hyperreactivity of the immune system and any cells, as well as humoral systems, to the pathogen.
5. Anergy is the second type of pathologically altered reduced reactivity, and it can be allergen-specific (immune) and non-immune. A kind of antigen-specific anergy to an infection agent may be immunity itself, although at first glance it seems absurd. But normergia is a normal immune response to infection, while hyperergic reponse is a disease.