CONCLUSION
With a wide range of phenotypes in EDS, combined early clinical and accurate molecular diagnosis can have a profound effect on the management of pregnant patients with EDS. As molecular diagnosis has become more widely available, subtyping EDS patients has become more accessible and the estimated prevalence is growing. One of the issues in studies investigating outcomes of pregnancy in EDS is the lack of clearly distinguished subtypes. Relying solely on isolated case reports does not provide a full picture of the scale of obstetric complications, with selection and reporting bias being a key issue. Regardless, certain dominant obstetric features in the classical and hypermobile subtypes have emerged: prematurity from cervical insufficiency or PROM, pelvic girdle pain or issues related to the pelvic floor. Perhaps of greater consequence, vascular EDS predisposes a significant risk of vessel rupture and perineal tears and may benefit from early caesarean delivery with specialist anaesthetic input. It is clear that further prospective research needs to be conducted in individuals with specific subtypes of EDS. With this in mind, the current review has attempted to highlight the obstetric complications of each subtype and to suggest potential management considerations based on clinical features and the limited evidence base.