Captions to the figures
Table 1: Rows describe how each of the natural amino acids has been replaced by column residues. Colors refer to the number of codon nucleotides involved in mutations: green, yellow and red indicate respectively one, two and three nucleotide changes.
Table 2: Table cells are colored according to BLOSUM62 matrix values: cyan, orange and magenta refer respectively to positive (favorable change), 0 to -1 (less favorable changes) and <-1 (unfavorable changes) values. Both rows and columns totals diverge from 10,000 due to figure rounding.
Table 3: In parenthesis, data for benign missense mutations; percentages are calculated for mutations in PISA databases and, with bold figures, in PISA interfaces.
Figure 1: Profiles of amino acid occurrences in missense mutations reported in ClinVar database. Benign and pathological mutations are shown in a and b respectively.
Figure 2: Cartoon representations of two proteins bearing three ClinVar BMMs involving arginine. Mutants are obtained from wild type structures by using PyMOL mutation routine and its Optimize plugin.