Captions to the figures
Table 1: Rows describe how each of the natural amino acids has
been replaced by column residues. Colors refer to the number of codon
nucleotides involved in mutations: green, yellow and red indicate
respectively one, two and three nucleotide changes.
Table 2: Table cells are colored according to BLOSUM62 matrix
values: cyan, orange and magenta refer respectively to positive
(favorable change), 0 to -1 (less favorable changes) and <-1
(unfavorable changes) values. Both rows and columns totals diverge from
10,000 due to figure rounding.
Table 3: In parenthesis, data for benign missense mutations;
percentages are calculated for mutations in PISA databases and, with
bold figures, in PISA interfaces.
Figure 1: Profiles of amino acid occurrences in missense
mutations reported in ClinVar database. Benign and pathological
mutations are shown in a and b respectively.
Figure 2: Cartoon representations of two proteins bearing three
ClinVar BMMs involving arginine. Mutants are obtained from wild type
structures by using PyMOL mutation routine and its Optimize plugin.