Oral food challenges (OFC)
Open (single-blind) food challenges were supervised by trained practitioners using recommended threshold cumulative doses (20). Due to risk of severe anaphylaxis or refusal, only 59% of patients were investigated with OFC (range: 32% for shrimp-allergic to 100% for peanut-allergic patients). A negative OFC was defined by the absence of allergy symptoms after consumption of a cumulative dose of tested food: egg white (>5 g of cooked egg), cow’s milk (>8.5 oz/254 mL of raw milk), peanut (>8.7 g of roasted peanut Eq to 2.2 g of protein), hazelnut (>8.7 g of roasted hazelnut Eq to 1.3 g of protein), fish (>50 g Eq to 12.5 g of protein) or shrimp (>39 g Eq to 7.5 g of protein). Ongoing oral immunotherapy (OIT) was not considered as an exclusion criterion, as 31% of patients were receiving OIT at time of inclusion.