Statistics on the number of entries for each analyzed residue property or category in the dataset. (A) Statistics on mutations involving charged, alanine and the other residues, respectively, and exposed  or buried residues.  (B) Statistics on mutations involving different residue properties subdivided according size transformations between small (Ala, Cys, Ser, Thr and Val) and big (Asn, Asp, Glu, Phe, His, Ile, Lys, Leu, Met, Glu, Arg, Tyr) amino acids.