Residue-wise comparison in thermodynamic reversibility accuracy between the whole dataset and mutations not-involving charged residues. (A) Number of mutations in which each residue is involved in the whole dataset (in red) and excluding charged residues (in blue). (B) Comparison for the average \(\Delta\Delta G_R\) for the whole dataset (in red) and excluding charged residues (in blue) each residue in FEPc calculations.