Summary of Studies Showing Sex-Differences in Pharmacokinetics: Antihistamines
A single‐centre, single dose, open‐label, reference replicate, bioavailability study in 12 healthy males and 12 healthy females aged 18-45 years with a body mass index between 19-30 kg/m2 was completed to determine the effect of sex on the pharmacokinetics of doxylamine–pyridoxine 10 mg–10 mg delayed‐release tablets. Females had significantly larger AUC0-t and a higher CMax, for doxylamine compared to males101.