Summary of Studies Showing Sex-Differences in Pharmacokinetics:
Antihistamines
A single‐centre, single dose,
open‐label, reference replicate, bioavailability study in 12 healthy
males and 12 healthy females aged 18-45 years with a body mass index
between 19-30 kg/m2 was completed to determine the
effect of sex on the pharmacokinetics of doxylamine–pyridoxine 10
mg–10 mg delayed‐release tablets. Females had significantly larger
AUC0-t and a higher CMax, for doxylamine
compared to males101.