Summary of Studies Showing Sex-Differences in Pharmacokinetics:
Scopolamine
An open label crossover study of 7
men and 7 women of mean age 23 years and in good health was completed to
identify any sex differences in pharmacokinetics in the metabolism of
0.5 mg scopolamine when given IV or orally with or without grapefruit
juice. The CMax was significantly higher in males than
females (6.61 ng/mL versus 3.93 ng/mL) after IV infusion with all other
parameters being similar102. No sex differences were
found in urinary elimination of scopolamine for any of the three
different routes of administration.
Age