Dupont, 2016 |
Measure tolerance of eHCF in infants 1-12 months with
confirmed CMPA |
At inclusion; day 14 |
N=30; mean
CoMiSSTM decreased from 7.4 to 3.2 after 14 days. Mean
CoMiSSTM at inclusion < 12. |
Rossetti, 2019 |
Evaluate hypoallergenicity of TeHCF in infants 1-36
months with suspected or diagnosed CMPA |
At inclusion; day 7, day 45,
day 90 |
N=29; mean CoMiSSTM at inclusion 1.4 ± 2.0.
No significant difference in COMISSTMTM score after 7 days. Maximum
score of 6 in 3/29 infants. |
Vandenplas, 2013 |
Measure efficacy of eWH and eCH in infants 0.5-6
months with suspected CMPA |
Before challenge; at inclusion; 1, 2, 4, 6,
8, 10 months |
N=116; mean SBS at inclusion 13.6 ± 2.2 in eWH and 13.8 ±
1.5 in eCH. SBS decreased by -8.3 in eWH and -7.8 in eCH groups at 1
month. Decrease to < 2 in both groups by 10
months. |
Vandenplas, 2014 |
Measure efficacy of eRHF in infants 0-6 months with
suspected CMPA |
Before challenge; at inclusion; 1, 3, 6 months |
N=38;
mean SBS 13.5 ±5.2 at inclusion. Significant decrease at each time point
(p<0.001). Decrease to < 2 by 6
months. |
Vandenplas, 2014 |
Evaluate hypoallergenicity of thickened versus non
thickened eCH in infants < 6 months with suspected CMPA |
At
inclusion; 1 month |
N=72; mean SBS 14.1 at inclusion. Decrease by -7.4
± 5.5 after 1-month intervention. Statistically stronger decrease in
CMPA+ group than CMPA- group (p<0.05). |
CMPA – cow’s milk protein allergy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMPA – cow’s milk protein allergy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMPA – cow’s milk protein allergy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMPA – cow’s milk protein allergy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|