Study
Score at presentation, Mean ± SD / Median [IQR]
Cut-off score
Total infants included in analysis
Total patients with confirmed CMPA, % prevalence
TP
FP
FN
TN
Sensitivity [95% CI]
Specificity [95% CI]
CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire CMPA questionnaire
Gibbons, 2012
10.7 ± 4.3 in cases 3.7 ± 2.8 in controls
≥ 6 (max 24)
84
51% (43/84)
38
12
5
29
0.88 [0.75, 0.96]
0.71 [0.54, 0.84]
Gibbons, 2012
8.7 ± 3.3 in cases 2.3 ± 2.2 in controls
≥ 6 (max 15)
84
51% (43/84)
38
3
9
38
0.81 [0.67, 0.91]
0.93 [0.80, 0.98]
CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version) CoMiSSTM (or its earlier SBS version)
At presentation At presentation At presentation At presentation At presentation At presentation At presentation At presentation At presentation At presentation At presentation
Prasad, 2018 16.2 ± 6.8 ≥ 12 83 84% (70/83) 55 8 15 5 0.79 [0.67, 0.87] 0.38 [0.14, 0.68]
Salvatore, 2019 8 [2-16] ≥ 9 47 40% (19/47) 16 4 3 24 0.84 [0.60, 0.97] 0.86 [0.67, 0.96]
Salvatore, 2019 8 [2-16] ≥ 12 47 40% (19/47) 7 2 12 26 0.37 [0.16, 0.62] 0.93 [0.76, 0.99]
Sirin Kose, 2019 13 [11-16] ≥ 10 49 100% (49/49) 43 - 6 - 0.88 [0.75, 0.95] Not estimable
Sirin Kose, 2019 13 [11-16] ≥ 12 49 100% (49/49) 34 - 15 - 0.69 [0.55, 0.82] Not estimable
Vandenplas, 2014 13.65 ± 1.5 ≥ 12 84 69% (58/84) 58 - 26 - 0.69 [0.58, 0.79] Not estimable
Zeng, 2019
7.4 ± 2.3 in CMPA+ 4.1 ± 1.6 in CMPA-
≥ 5.5
38
63% (24/38)
21
3
3
11
0.88 [0.68, 0.97]
0.79 [0.49, 0.95]
At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED At 1-month after ED
Sirin Kose, 2019 - ≥ 25% decrease after 4-week ED 49 100% (49/49) 48 - 1 - 0.98 [0.89, 1.00] Not estimable
Sirin Kose, 2019 - ≥ 50% decrease after 4-week ED 49 100% (49/49) 41 - 8 - 0.84 [0.70, 0.93] Not estimable
Vandenplas, 2014 - ≥ 50% decrease after 4-week ED 85 69% (59/85) 45 11 14 15 0.76 [0.63, 0.86] 0.58 [0.37, 0.77]
discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative discrepancies in the reported data were identified. Presented here is the reported two-by-two data with test accuracy estimates calculated in Review Manager. CMPA – cow’s milk protein ED – elimination diet IQR – inter-quartile range SBS – symptom-based score SD – standard deviation TP – true positive TN – true negative FP – false positive FN – false negative