Study |
Country |
Study type |
Study
aim and use of symptom score |
Sample size |
Conflict
of interests with industry |
Bigorajska, 2020 |
Poland |
Observational |
Validation of
CoMiSSTM to determine age-related scores in presumed
healthy infants < 6 months |
n = 226 |
Yes |
Dupont, 2016 |
United Kingdom |
Observational |
Evaluate tolerance of
eHCF in infants 1-12 months with confirmed CMPA using
CoMiSSTM as an outcome measure for symptom resolution |
n = 30 |
Yes |
Gibbons, 2012 |
United States |
Two gate DTA |
Estimate the test
accuracy of CMPA questionnaire in the early identification of non-IgE
mediated CMPA in infants < 24 months |
n = 84 |
No |
Prasad, 2018 |
India |
Single gate DTA |
Estimate the test accuracy of
CoMiSSTM in the early identification of CMPA in
infants 0-24 months with suspected CMPA |
n = 83 |
Yes |
Rossetti, 2019 |
Italy |
Observational |
Evaluate hypoallergenicity of
TeHCF in infants 1-36 months with suspected or diagnosed CMPA using
CoMiSSTM as an outcome measure for symptom resolution |
n = 29 |
No |
Salvatore, 2019 |
Italy |
Single gate DTA |
Estimate the test accuracy
of CoMiSSTM in identifying infants who would benefit
from CMFD when CMPA is suspected in infants 1-12 months |
n = 47 |
No |
Sirin Kose, 2019 |
Turkey |
Single arm of two gate DTA |
Estimate the
test accuracy of SBS performed after a 4-week elimination diet in
infants 0-10 months diagnosed with CMPA and/or HEA |
n = 49 |
No |
Vandenplas, 2013 |
Belgium |
RCT |
Evaluate the efficacy of eWH and eCH
in infants 0.5-6 months with suspected CMPA using SBS as an outcome
measure for symptom resolution |
n = 85 |
Yes |
Vandenplas, 2014 |
Belgium |
Single gate DTA |
Estimate the test
accuracy of SBS performed after a 4-week elimination diet in infants
aged 0-6 months to select those with a likely diagnosis of CMPA |
n = 85 |
Yes |
Vandenplas, 2014 |
Belgium |
Observational |
Evaluate the efficacy of
eRHF in infants 0-6 months with suspected CMPA using SBS as an outcome
measure for symptom resolution |
n = 38 |
Yes |
Vandenplas, 2014 |
Allar Study Group: Belgium, Greece, Kuwait, Lebanon,
Slovenia |
RCT |
Evaluate hypoallergenicity of thickened versus non
thickened eCH in infants < 6 months with suspected CMPA using
SBS as an outcome measure for symptom resolution |
n = 72 |
Yes |
Vandenplas, 2015 |
Belgium |
Development |
Workshop report for consensus
on adapting the SBS as an awareness tool to recognise cow’s milk related
symptoms in young children |
- |
Yes |
Vandenplas, 2018 |
Belgium, Italy, Poland, Spain |
Observational |
Validation of CoMiSSTM to determine age-related scores
in presumed healthy infants < 6 months |
n = 413 |
Yes |
Vandenplas, 2019 |
Spain, Belgium |
Observational |
Validation of
CoMiSSTM to investigate inter-rater reliability and
day-to-day variability between scores by parents and healthcare
professionals in presumed healthy infants < 6 months |
n = 220 |
Yes |
Zeng, 2019 |
China |
Single gate DTA |
Estimate test accuracy of
CoMiSSTM in early identification of CMPA in infants
1-12 months with suspected CMPA |
n = 38 |
Yes |
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
DTA – diagnostic test accuracy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
HEA – hen egg allergy
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
DTA – diagnostic test accuracy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
HEA – hen egg allergy
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
DTA – diagnostic test accuracy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
HEA – hen egg allergy
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
DTA – diagnostic test accuracy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
HEA – hen egg allergy
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
DTA – diagnostic test accuracy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
HEA – hen egg allergy
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|
CMFD – cow’s milk free diet
CMPA – cow’s milk protein allergy
DTA – diagnostic test accuracy
eCH – extensive casein hydrolysate
eHCF – extensively hydrolysed casein-based formula
eRHF – extensive rice hydrolysate formula
eWH – extensive whey hydrolysate
HEA – hen egg allergy
SBS – symptom-based score (early version of CoMiSSTM)
TeHCF – thickened extensively hydrolysed casein-based formula
|