Study Country Study type Study aim and use of symptom score Sample size Conflict of interests with industry
Bigorajska, 2020 Poland Observational Validation of CoMiSSTM to determine age-related scores in presumed healthy infants < 6 months n = 226 Yes
Dupont, 2016 United Kingdom Observational Evaluate tolerance of eHCF in infants 1-12 months with confirmed CMPA using CoMiSSTM as an outcome measure for symptom resolution n = 30 Yes
Gibbons, 2012 United States Two gate DTA Estimate the test accuracy of CMPA questionnaire in the early identification of non-IgE mediated CMPA in infants < 24 months n = 84 No
Prasad, 2018 India Single gate DTA Estimate the test accuracy of CoMiSSTM in the early identification of CMPA in infants 0-24 months with suspected CMPA n = 83 Yes
Rossetti, 2019 Italy Observational Evaluate hypoallergenicity of TeHCF in infants 1-36 months with suspected or diagnosed CMPA using CoMiSSTM as an outcome measure for symptom resolution n = 29 No
Salvatore, 2019 Italy Single gate DTA Estimate the test accuracy of CoMiSSTM in identifying infants who would benefit from CMFD when CMPA is suspected in infants 1-12 months n = 47 No
Sirin Kose, 2019 Turkey Single arm of two gate DTA Estimate the test accuracy of SBS performed after a 4-week elimination diet in infants 0-10 months diagnosed with CMPA and/or HEA n = 49 No
Vandenplas, 2013 Belgium RCT Evaluate the efficacy of eWH and eCH in infants 0.5-6 months with suspected CMPA using SBS as an outcome measure for symptom resolution n = 85 Yes
Vandenplas, 2014 Belgium Single gate DTA Estimate the test accuracy of SBS performed after a 4-week elimination diet in infants aged 0-6 months to select those with a likely diagnosis of CMPA n = 85 Yes
Vandenplas, 2014 Belgium Observational Evaluate the efficacy of eRHF in infants 0-6 months with suspected CMPA using SBS as an outcome measure for symptom resolution n = 38 Yes
Vandenplas, 2014 Allar Study Group: Belgium, Greece, Kuwait, Lebanon, Slovenia RCT Evaluate hypoallergenicity of thickened versus non thickened eCH in infants < 6 months with suspected CMPA using SBS as an outcome measure for symptom resolution n = 72 Yes
Vandenplas, 2015 Belgium Development Workshop report for consensus on adapting the SBS as an awareness tool to recognise cow’s milk related symptoms in young children - Yes
Vandenplas, 2018 Belgium, Italy, Poland, Spain Observational Validation of CoMiSSTM to determine age-related scores in presumed healthy infants < 6 months n = 413 Yes
Vandenplas, 2019 Spain, Belgium Observational Validation of CoMiSSTM to investigate inter-rater reliability and day-to-day variability between scores by parents and healthcare professionals in presumed healthy infants < 6 months n = 220 Yes
Zeng, 2019 China Single gate DTA Estimate test accuracy of CoMiSSTM in early identification of CMPA in infants 1-12 months with suspected CMPA n = 38 Yes
CMFD – cow’s milk free diet CMPA – cow’s milk protein allergy DTA – diagnostic test accuracy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate HEA – hen egg allergy SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMFD – cow’s milk free diet CMPA – cow’s milk protein allergy DTA – diagnostic test accuracy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate HEA – hen egg allergy SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMFD – cow’s milk free diet CMPA – cow’s milk protein allergy DTA – diagnostic test accuracy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate HEA – hen egg allergy SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMFD – cow’s milk free diet CMPA – cow’s milk protein allergy DTA – diagnostic test accuracy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate HEA – hen egg allergy SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMFD – cow’s milk free diet CMPA – cow’s milk protein allergy DTA – diagnostic test accuracy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate HEA – hen egg allergy SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula CMFD – cow’s milk free diet CMPA – cow’s milk protein allergy DTA – diagnostic test accuracy eCH – extensive casein hydrolysate eHCF – extensively hydrolysed casein-based formula eRHF – extensive rice hydrolysate formula eWH – extensive whey hydrolysate HEA – hen egg allergy SBS – symptom-based score (early version of CoMiSSTM) TeHCF – thickened extensively hydrolysed casein-based formula