Funding Statement
This work was supported by the National Natural Science Foundation of China (No. 81801557, 81874169, 82171810), Natural Science Foundation of Shandong Province (No. ZR2020KH033, ZR2021MH287, ZR2020MH163), the Doctoral Startup Fund of Jining Medical University (No. JY2016QD030), NSFC cultivation project of Jining Medical University (No. JYP2018KJ22), Projects of Medical and Health Technology Development Program in Shandong Province (No. 2019WS356).