References
[1]Silver SA, Devouassoux-Shisheboran M, Mezzetti TP, Tavassoli FA. Mesonephric adenocarcinomas of the uterine cervix: a study of 11 cases with immunohistochemical findings. Am J Surg Pathol . 2001; 25(3):379-387.
[2]Nomoto K, Hayashi S, Tsuneyama K, Hori T, Ishizawa S. Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases. Cytopathology . 2013;24(2):129-131.
[3]Wilbur DC,Chhieng DC,Guidos B,Mody DR.Epithelial Abnormalities: Glandular. In: Nayar R, Wilbur DC, eds. The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria and Explanatory Notes . 3rd ed. London, United Kingdom: Springer; 2015:206-210
[4]Liang Y, Shi H, Zhu X, Yu M, Zhang X. Mesonephric Adenocarcinoma of the Uterine Corpus: A Report on 2 Cases With Comparison to Its Cervical Counterpart. Int J Gynecol Pathol. 2020 Jan 23. doi: 10.1097/PGP.0000000000000639.
[5]Kezlarian B, Muller S, Werneck Krauss Silva V, et al. Cytologic features of upper gynecologic tract adenocarcinomas exhibiting mesonephric-likedifferentiation. Cancer Cytopathol . 2019; 127(8):521-28
[6]McFarland M, Quick CM, McCluggage WG. Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of mesonephric-like adenocarcinomas. Histopathology . 2016; 68(7):1013-1020.
[7]Howitt BE, Emori MM, Drapkin R, Gaspar C, Barletta JA, Nucci MR, McCluggage WG, Oliva E, Hirsch MS. GATA3 Is a Sensitive and Specific Marker of Benign and Malignant Mesonephric Lesions in the Lower Female Genital Tract. Am J Surg Pathol . 2015; 39(10):1411-9.
[8]Hejmadi RK, Gearty JC, Waddell C, Ganesan R. Mesonephric hyperplasia can cause abnormal cervical smears: report of three cases with review of literature. Cytopathology . 2005;16(5):240-243.
[9]Skala SL, Gregg PA, Orr JW Jr, Udager AM, Brown NA, Cho KR. Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation. Int J Gynecol Pathol . 2019 Jul 18. doi: 10.1097/PGP.0000000000000627.
[10]Pors J, Cheng A, Leo JM, Kinloch MA, Gilks B, Hoang L. A Comparison of GATA3, TTF1, CD10, and Calretinin in Identifying Mesonephric and Mesonephric-like Carcinomas of the Gynecologic Tract.Am J Surg Pathol . 2018; 42(12):1596-1606.
[11]Horn LC, Höhn AK, Krücken I, Stiller M, Obeck U, Brambs CE. Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma. J Cancer Res Clin Oncol . 2020; 146(4):971-983.
Figure 1 (A) A neoplastic gland composed of overlapping tumor cells (liquid-based cytology test, Papanicolaou,×400) .(B) Endocervical cells with picket fence appearance (brown arrow) and scattered tumor cells (pink arrow) in the dirty background(liquid-based cytology test, Papanicolaou,×400).(C)Some tumor cells with irregular nuclear membranes and coarse chromatin (black arrow, liquid-based cytology test, Papanicolaou,×400).
Figure 2 (A) Some well-differentiated tubular glands containing eosinophilic luminal secretions(HE stain, ×400). (B) Positive Gata-3 staining(Envision,×400). (C) Tumor cells positive for vimentin(Envision,×400).
Figure 3 (A) The gross appearance of the mass located in the the uterine cavity and cervical canal. (B) Histology showing the hyperplastic mesonephric remnants(violet arrow) and neoplastic mesonephric glands(red arrow) very close to normal endocervical glands (blue arrow,HE stain, ×200). (C) The hyperplastic mesonephric glands (green arrow) accompanied with neoplastic glands (black arrow) in the stroma( HE stain, ×400). (D) Tumor glands(pink arrow) showing higher ki-67 proliferative index than hyperplastic mesonephric glands(yellow arrow, HE stain, ×400).