Transplant details and GVHD prophylaxis
Both donor types (related or unrelated) contained matched or mismatched
grafts. Graft sources were derived from bone marrow, peripheral blood,
or cord blood. All conditioning regimens utilized for the eligible
patients involved MAC with 12 or 13.2 Gy of TBI. TBI was administered to
the patients in six fractions (two fractions per day). Different GVHD
prophylaxis was adopted according to the administered graft source. GVHD
prophylaxis for cord blood transplantation (CBT) consists of cyclosporin
(CSA) and methylprednisolone. Most GVHD prophylaxis for HCT from the
graft of a related donor consisted of CSA and methotrexate (MTX).
Prophylaxis for HCT from a graft of an unrelated donor consisted of
tacrolimus and MTX.