Results
The median D-index of the children was significantly higher than that of
the AYAs (8,187, range, 0−20,095 vs. 6,446, range, 0−10,532,
respectively, P = 0.017) (Figure 1). Similarly, the median
duration of neutropenia was also significantly longer in children than
in AYAs (24.0 days, range, 0−59 days vs. 11.5 days, range, 0−36 days,
respectively, P = 0.007) (Figure 2). In terms of infectious
complications during induction chemotherapy for ALL, FN occurred in
53.7% of the analyzed patients, with 55.6% in children and 42.9% in
AYAs; however, the incidence of FN was not statistically different
between the two groups (P = 0.401). Moreover, bacteremia and IFI
were observed in 9.5% and 2.1% of the analyzed patients, respectively.
These incidences were also not significantly different between children
and AYAs (bacteremia: 8.6% vs. 14.3%, respectively, P = 0.617,
IFI: 1.2% vs. 7.1%, respectively, P = 0.274).