Details of Ethics Approval
The experimental protocol was approved by the Institutional Review Board
for the Care of Animal Subjects of the National Defense Medical College
(ethical approval number: #17032, 07/08/2017). All applicable
international, national, and/or institutional guidelines for the care
and use of animals were followed.
Funding. This work was supported in part by JSPS KAKENHI (grant
number 19K09760 (Y.Y., M.M., K.H., M.K., and K.T.) and AMED (grant
numbers 18lk14030XXh0002 and 19lk1403022h0002 (M.K. and H.S.) from Japan
Agency for Medical Research Development.