Main Findings
This study developed a severe PPH model after caesarean section using pregnant rabbits. Total haemorrhage was approximately at least 50 mL/kg and led to severe PPH that became lethal within a few hours in the absence of any fluid resuscitation. As a result, we established an appropriate animal model requiring massive transfusion according to actual clinical practice. Using the current PPH model, we demonstrated that HbVs helped to maintain haemodynamics for severe PPH. The acute prognosis was better than that achieved with administration of HES, resulting in a drastic reduction of mortality.