Experimental Protocol
All procedures involving animals were reviewed and approved by Kyung Hee University Institutional Animal Care and Use committee [KHUASP(SE)-18-124]. A549 xenograft model was established and athymic nu/nu female mice were randomized into following four different treatment groups (n=6/group). Tumor volumes were measured by Digimatic caliper every 5 days and mice body weight was measured about 2 or 3 day intervals. Mice were killed 5 days later after last therapy and tumor tissues were further processed as described before (Jung et al., 2019)