Experimental Protocol
All procedures involving animals were reviewed and approved by Kyung Hee
University Institutional Animal Care and Use committee
[KHUASP(SE)-18-124]. A549 xenograft model was established and
athymic nu/nu female mice were randomized into following four different
treatment groups (n=6/group). Tumor volumes were measured by Digimatic
caliper every 5 days and mice body weight was measured about 2 or 3 day
intervals. Mice were killed 5 days later after last therapy and tumor
tissues were further processed as described before
(Jung et al., 2019)