GGC alters levels of various oncogenic markers.
First as measured by immunohistochemical analysis it found that GGC treatment caused a marked down-regulation in the expression of p-STAT3, Ki-67, and VEGF proteins (Fig. 6A). Thereafter, as shown Fig. 6B, GGC increased PTPε protein level but decreased the levels of phopho-STAT3 and different phosphorylated kinases as measured by western blotting. Next, cleaved caspase-3 and PARP levels were significantly elevated in tissues harvested from GCC exposed mice (Fig. 6D). Finally, GGC reduced the expression of diverse oncogenic proteins that can regulate tumorigenesis in NSCLC model (Fig. 5E).