GGC alters levels of various oncogenic markers.
First as measured by immunohistochemical analysis it found that GGC
treatment caused a marked down-regulation in the expression of p-STAT3,
Ki-67, and VEGF proteins (Fig. 6A). Thereafter, as shown Fig. 6B, GGC
increased PTPε protein level but decreased the levels of phopho-STAT3
and different phosphorylated kinases as measured by western blotting.
Next, cleaved caspase-3 and PARP levels were significantly elevated in
tissues harvested from GCC exposed mice (Fig. 6D). Finally, GGC reduced
the expression of diverse oncogenic proteins that can regulate
tumorigenesis in NSCLC model (Fig. 5E).