Improved outcome after Wilms tumor treatment in Sudan: a 10-year
single-center experience
Abstract
Abstract Background: the survival of Wilms tumor is very low when
evaluated in 2008. The impact of establishing pediatric oncology service
on survival is studied, and the obstacles of treating Wilms tumor
patients were identified. Procedure: All Wilms tumor patients from 2005
to 2014 were analyzed retrospectively. Patients received treatment based
on the NWTS IV protocol. Patients were analyzed for overall survival,
and event-free survival, and these outcomes were correlated with age,
sex, stage at presentation, and histology. Results: We analyzed 143
files of Wilms tumor. The male to female ratio is 1.75. The mean age of
patients at diagnosis is 3.5. The follow-up period is five years. Most
patients (83%) had advanced disease stage 3, and 4.There is a very high
abandonment rate (37%). The event-free survival among patients who
completed treatment is 75.6%, and the overall survival is 43.4%
Conclusions: There is a remarkable improvement in Wilms tumor survival
from 11% to 43 % and 75.6%. Much needs to be done to reduce
abandonment rates and establish a surgical pediatric oncology service.