3.1 Inhaled rosuvastatin reversed the decreases in the expression and activity of brainstem CD73 in ovalbumin (OVA)-sensitized rats
In OVA-sensitized rats, both the expression and activity of CD73 (Fig.1A-C) in the nucleus ambiguus (NA)-containing region of medulla were significantly decreased; and, consistently, ATP concentration in cerebral spinal fluid (CSF) (Fig.1D) was significantly increased. In rosuvastatin-treated rats, all of these changes were reversed by inhaled rosuvastatin (Fig.1A-D).