Figure 1
3.2 Inhaled rosuvastatin abolished the increase of airway
vagal activity in OVA-sensitized rats
In OVA-sensitized rats, both the inspiratory resistance of the airway
(Ri) and expiratory resistance of the airway
(Re) were significantly increased (Fig.2A1, B1), and,
consistently, the dynamic compliance of the lungs (Cdyn)
was significantly decreased (Fig.2C1). In rosuvastatin-treated rats,
Ri, Re and Cdyn are not
significantly different with those of rats in control group (Fig.2A1,
B1, C1; ANOVA test). 20 min after intraperitoneal injection of atropine
sulphate (0.5 mg·kg-1), Ri,
Re and Cdyn in rats of different groups
are no longer significantly different (Fig.2A2, B2, C2; ANOVA test). In
addition, atropine treatment significantly decreased Riand Re, and significantly increased Cdynin OVA-sensitized rats, but did not cause any significant change in the
Ri, Re and Cdyn of rats
in control group and treatment group (Fig.2A3, B3, C3; pairedt -test).