Figure legends
Figure 1. Inhaled rosuvastatin reversed the decreases in the
expression and activity of brainstem CD73 in OVA-sensitized rats. The
expression of CD73 in NA-containing brain tissue was assayed with
Western-blot; and the activity was measured with molecular biological
methods. Note in OVA-sensitized rats, both the expression and activity
of CD73 were significantly decreased, leading to significantly increased
ATP concentration in cerebral spinal fluid, and all of which were
reversed by inhaled rosuvastatin in rosuvastatin-treated rats. P values
were obtained from one-way ANOVA.
Figure 2. Inhaled rosuvastatin abolished the increase of airway
vagal activity in OVA-sensitized rats. (A1, B1 and C1) The bar
graphs of inspiratory resistance of the airway (Ri),
expiratory resistance of the airway (Re) and dynamic
compliance of the lungs (Cdyn) measured using
plethysmography, showing that in OVA-sensitized rats, Riand Re were significantly increased;
Cdyn was significantly decreased, and all of which were
reversed by inhaled rosuvastatin in rosuvastatin-treated rats. (A2, B2
and C2) The bar graphs of Ri, Re and
Cdyn 20 min after intraperitoneal injection of atropine
sulphate (0.5 mg·kg-1), showing that the changes
induced by OVA sensitization were abolished. (A3, B3 and C3) comparison
of Ri, Re and Cdynbefore and after atropine treatment in rats of different groups, showing
that atropine significantly decreased Ri and
Re, and significantly increased Cdyn in
OVA-sensitized rats, but did not cause any change in Ri,
Re and Cdyn of control and
rosuvastatin-treated rats. P values in the left and middle columns were
obtained from one-way ANOVA; P values in the right column was obtained
from paired t -test.
Figure 3. Inhaled rosuvastatin reversed the increase in the
expression of ECP1 in the lungs of OVA-sensitized rats . P values were
obtained from one-way ANOVA.