demographics gender, age
subjective clinical data at baseline- personal and family medical history- atopy status, allergic rhinitis (AR), atopic dermatitis (AD), food allergy and other comorbidities
objective clinical data
at baseline and after 6 months - symptom control, frequency and severity of exacerbations in the period since the last visit, lung function (FVC, FEV1, MEF50), airway inflammation (FENO) measurement and medication use; at baseline - skin prick (SPT) and total and specific IgE to inhaled allergens, blood eosinophils and neutrophils, anthropometric measures (height, weight, body mass index ) and for certain patients with suggestive history for comorbidities -ENT examination, pH probing with impedance for diagnostics of laryngopharyngeal reflux and gastroesophageal reflux disease, polysomnography for diagnostics of obstructive sleep apnoea syndrome, SPT and specific IgE to food and insect venom allergens for diagnostics of food/insect venom allergy
genetic data genotypes for rs37973 (GLCCI1), rs9910408 (TBX21), rs242941 (CRHR1), rs1876828 (CRHR1), rs1042713 (ADRB2) and rs17576 (MMP9)