Contribution to authorship
AK, FTW, MA and TU contributed equally to conceive, design and oversee the conduct of this review. This included executing the literature search, acquisition, analysis and interpretation of the literature. AK critically reviewed ‘the diagnostic role’, FTW ‘the prognostic role’, MA ‘the therapeutic role’ and TU ‘intermediate-high risk group’ for the latter two ‘role’ categories. All authors were involved in drafting the first revision of the manuscript, critically responding to peer-reviewer’s comments (Supplementary information 1) and producing the amended revision that is this manuscript. We certify that all authors are responsible for the content of this manuscript and have read and approved of the final version. Order of authorship was decided alphabetically.