Imatinib:
Imatinib (Gleevec) is an oral chemotherapeutic drug used for the
treatment of various cancers. It acts by blocking tyrosine kinase
receptors. The anti-viral activity of the imatinib is because of its
ability to inhibit the infusion of virions with the endosomal membrane.
Hoffmann et al. indicated that, to enter target cells, SARS-CoV-2 uses
ACE2, the cellular protease TMPRSS2, and the SARS-CoV receptor. Imatinib
is a potent inhibitor of TMPRSS2 and thus can be used as a treatment
option. However, further in-vivo and clinical studies needed with the
aim to decide the efficacy profile, safety, and adverse reactions of the
drug.