Imatinib:
Imatinib (Gleevec) is an oral chemotherapeutic drug used for the treatment of various cancers. It acts by blocking tyrosine kinase receptors. The anti-viral activity of the imatinib is because of its ability to inhibit the infusion of virions with the endosomal membrane. Hoffmann et al. indicated that, to enter target cells, SARS-CoV-2 uses ACE2, the cellular protease TMPRSS2, and the SARS-CoV receptor. Imatinib is a potent inhibitor of TMPRSS2 and thus can be used as a treatment option. However, further in-vivo and clinical studies needed with the aim to decide the efficacy profile, safety, and adverse reactions of the drug.