3.2 Nicorandil decreases patient blood pressure in a
concentration-dependent manner
In this study, the intravenous pumping rate of Nicorandil was adjusted
according to the patient’s blood pressure levels, and the effect of
different concentrations of Nicorandil on the patient’s SBP and DBP was
observed(Table 2). It was found that the systolic blood pressure of
the patients can be significantly reduced compared with the baseline
blood pressure when the pumping rate of Nicorandil at 4 mg/h and 6 mg/h,
respectively (p < 0.01) ( Figure 1). And the reduction in
systolic blood pressure was 18.00±18.01, 27.04±17.25 respectively. And
compared with the baseline DBP,the levels of DBP decreased
significantly when the pumping rate of Nicorandil were 4 mg/h and 6 mg/h
(p < 0.01) (Figure 2). And the reduction in DBP was 8.71± 9.01
and 15.17±12.93, respectively. But when the pumping speed is 2 mg/h,
there is no significant statistical changes compared with the baseline
SBP and DBP. (p > 0.05) (Figure 1 and Figure 2 ). These
showed that Nicorandil could decrease patients blood pressure in a
concentration-dependent manner.