The major adverse reactions of this drug were headache,hepatic function disorder, thrombocytopenia, increased total bilirubin, increased LDH, anemia, and increased γ-GTPetc18,19. In our trial, patients also experienced dizziness, headache, blushing and other discomforts, but the difference is that one patient developed orthostatic hypotension, and its possible mechanism may be related to the rapid infusion of Nicorandil which resulted in a rapid drop in blood pressure.
In our trials, we found that Intravenous Nicorandil had a significant effect in blood pressure lowering and was also safe. Because the sample size of this study is relatively small, and most of our patients are elderly, they may not represent the entire population, so a larger and more comprehensive clinical trial is needed. As the trial progresses, Intravenous Nicorandil may be used, like nitroglycerin, to relieve angina, and the same time, to lower blood pressure. However, we should pay more attention to the pumping speed of nicorandil in the process of using Nicorandil, especially to the elderly, and we must try our best to avoid the risk of orthostatic hypotension.