The major adverse reactions of this drug were
headacheļ¼hepatic function disorder, thrombocytopenia, increased total
bilirubin, increased LDH, anemia, and increased
γ-GTPetc18,19. In our trial, patients also experienced
dizziness, headache, blushing and other discomforts, but the difference
is that one patient developed orthostatic hypotension, and its possible
mechanism may be related to the rapid infusion of Nicorandil which
resulted in a rapid drop in blood
pressure.
In our trials, we found that Intravenous Nicorandil had a significant
effect in blood pressure lowering and was also safe. Because the sample
size of this study is relatively small, and most of our patients are
elderly, they may not represent the entire population, so a larger and
more comprehensive clinical trial is needed. As the trial progresses,
Intravenous Nicorandil may be used, like nitroglycerin, to relieve
angina, and the same time, to lower blood pressure. However, we should
pay more attention to the pumping speed of nicorandil in the process of
using Nicorandil, especially to the elderly, and we must try our best to
avoid the risk of orthostatic hypotension.