Disposition/Reason
All patients N=32 n (%)
Pharmacokinetic phase (DDI phase)
Completed 26 (81.3)
Entered post-DDI (treatment) phase 26 (81.3)
Discontinued from PK phase
6 (18.8)
Entered post-DDI (treatment) phase 1 (3.1)
Entered post-treatment follow-up phase 1 (3.1)
Primary reason for discontinuation from PK phase
Adverse event 2 (6.3)
Physician decision 2 (6.3)
Progressive disease 1 (3.1)
Death 1 (3.1)
Post-DDI (treatment) phase
Discontinued from post-DDI (treatment) phase 27 (84.4)
Primary reason for discontinuation from treatment phase
Progressive disease 20 (62.5)
Physician decision 3 (9.4)
Death 2 (6.3)
Adverse event 1 (3.1)
Lost to follow-up 1 (3.1)
Post-treatment follow-up
Discontinued from post-treatment follow-up 1 (3.1)
Primary reason for discontinuation from post-treatment follow-up
Protocol deviation 1 (3.1)