PK parameter by probe drug n Adjusted geo-mean Treatment comparison
Geo-mean ratio (90% CI)
Digoxin
AUCinf (ng × h/mL)
Probe drug alone 9 22.4 1.47 (1.28- 1.68)
Probe drug + capmatinib 12 32.9
AUClast (ng × h/mL)
Probe drug alone 25 14.6 1.63 (1.42-1.89)
Probe drug + capmatinib 25 23.8
Cmax (ng/mL)
Probe drug alone 25 1.12 1.74 (1.43-2.13)
Probe drug + capmatinib 25 1.95
Rosuvastatin
AUCinf (ng × h/mL)
Probe drug alone 21 75.2 2.08 (1.56-2.76)
Probe drug + capmatinib 22 156
AUClast (ng × h/mL)
Probe drug alone 24 71 2.03 (1.61-2.56)
Probe drug + capmatinib 24 144
Cmax (ng/mL)
Probe drug alone 24 7.72 3.04 (2.36-3.92)
Probe drug + capmatinib 24 23.5