PK parameter by probe drug
|
n |
Adjusted geo-mean |
Treatment
comparison |
|
|
|
Geo-mean ratio (90% CI) |
Digoxin |
|
|
|
AUCinf (ng × h/mL)
|
|
|
|
Probe drug alone |
9 |
22.4 |
1.47 (1.28- 1.68) |
Probe drug + capmatinib |
12 |
32.9 |
|
AUClast (ng × h/mL)
|
|
|
|
Probe drug alone |
25 |
14.6 |
1.63 (1.42-1.89) |
Probe drug + capmatinib |
25 |
23.8 |
|
Cmax (ng/mL) |
|
|
|
Probe drug alone |
25 |
1.12 |
1.74 (1.43-2.13) |
Probe drug + capmatinib |
25 |
1.95 |
|
Rosuvastatin |
|
|
|
AUCinf (ng × h/mL)
|
|
|
|
Probe drug alone |
21 |
75.2 |
2.08 (1.56-2.76) |
Probe drug + capmatinib |
22 |
156 |
|
AUClast (ng × h/mL)
|
|
|
|
Probe drug alone |
24 |
71 |
2.03 (1.61-2.56) |
Probe drug + capmatinib |
24 |
144 |
|
Cmax (ng/mL) |
|
|
|
Probe drug alone |
24 |
7.72 |
3.04 (2.36-3.92) |
Probe drug + capmatinib |
24 |
23.5 |
|