aMedian (min, max) is reported for
Tmax.
n=number of patients with corresponding evaluable pharmacokinetic
parameters.
Abbreviations: AUCinf, area under the concentration-time
curve from time zero to infinity; AUClast, area under
the concentration-time curve from time zero to the last quantifiable
concentration; CL/F, apparent total body clearance from plasma;
Cmax, maximum concentration; Geo-CV, geometric
coefficient of variation; Geo-mean, geometric mean;
T1/2, elimination half-life determined as
0.693/λz; Tmax,
time to reach maximum plasma concentration; λz, terminal elimination
rate constant; Vz/F, apparent volume of distribution during the terminal
elimination phase.