Pharmacokinetic
Parameters
|
Digoxin alone
N=25
|
Digoxin alone
N=25
|
Capmatinib + digoxin
N=25
|
Capmatinib + digoxin
N=25
|
Rosuvastatin alone
N=24
|
Rosuvastatin alone
N=24
|
Capmatinib + rosuvastatin
N=24
|
Capmatinib + rosuvastatin
N=24
|
|
n |
Geo-mean (Geo-CV%) |
n |
Geo-mean (Geo-CV%) |
n |
Geo-mean (Geo-CV%) |
n |
Geo-mean (Geo-CV%) |
AUCinf, ng h/mL |
9 |
25.3 (36.3) |
12 |
34.1 (37.9) |
21 |
78.2 (73.4) |
22 |
159 (99.8) |
AUClast, ng h/mL |
25 |
14.6 (58.0) |
25 |
23.8 (50.5) |
24 |
71.0 (71.3) |
24 |
144 (102.6) |
Cmax, ng/mL |
25 |
1.12 (57.9) |
25 |
1.95 (56.8) |
24 |
7.72 (73.4) |
24 |
23.5 (85.5) |
Tmax, ha
|
25
|
1.07
(0.500, 6.00)
|
25
|
1.00
(0.417, 4.08)
|
24
|
2.04
(0.500, 6.00])
|
24
|
1.55
(0.500, 9.93)
|
T1/2, h |
9 |
47 (29.8) |
12 |
61.4 (25.7) |
21 |
22
(73.8) |
22 |
21.4 (56.6) |
CL/F, L/h |
9 |
9.89 (36.3) |
12 |
7.33 (37.9) |
21 |
128 (73.4) |
22 |
62.8 (99.8) |
VZ/F, L |
9 |
671 (16.5) |
12 |
649 (22.3) |
21 |
4060
(80.2) |
22 |
1940 (105.1) |