Treatment Point estimate (%) (95% CI) P-value
SAD
0.3 mg -7 (-43.1; +51.9) 0.71
1 mg -15.4 (-45.7; +31.8) 0.37
3 mg -36.9 (-62.2; +5.3) 0.07
10 mg -23.5 (-48.4; +13.5) 0.12
30 mg -42.3 (-65.2; -4.3) 0.04
60 mg -46.2 (-60.3; -27.0) 0.002
100 mg -72.4 (-81.1; -59.5) 0.002
200 mg -48.6 (-65.3; -23.9) 0.006
400 mg -52.9 (-60.6; -43.6) <0.0001
600 mg -63.4 (-69.4; -56.1) <0.0001
MAD
30 mg BID -29.8 (-49.8; -2.0) 0.04
70 mg BID -46.3 (-61.7; -24.8) 0.001
150 mg BID -72.8 (-80.5; -62.1) <0.0001