Treatment |
Point estimate (%) (95% CI) |
P-value |
SAD |
|
|
0.3 mg |
-7 (-43.1; +51.9) |
0.71 |
1 mg |
-15.4 (-45.7; +31.8) |
0.37 |
3 mg |
-36.9 (-62.2; +5.3) |
0.07 |
10 mg |
-23.5 (-48.4; +13.5) |
0.12 |
30 mg |
-42.3 (-65.2; -4.3) |
0.04 |
60 mg |
-46.2 (-60.3; -27.0) |
0.002 |
100 mg |
-72.4 (-81.1; -59.5) |
0.002 |
200 mg |
-48.6 (-65.3; -23.9) |
0.006 |
400 mg |
-52.9 (-60.6; -43.6) |
<0.0001 |
600 mg |
-63.4 (-69.4; -56.1) |
<0.0001 |
MAD |
|
|
30 mg BID |
-29.8 (-49.8; -2.0) |
0.04 |
70 mg BID |
-46.3 (-61.7; -24.8) |
0.001 |
150 mg BID |
-72.8 (-80.5; -62.1) |
<0.0001 |