Statistical analysis
RStudio version 1.3.1093 software was used for all statistical analyses. Chi-square (χ2) significance test was used to detect significant relationships between various parameters and prognostic factors. Kaplan-Meier curve was used to analyze overall survival among follow-up cases. A p value<0.05 was considered statistically significant.  A multivariate COX regression hazard model was applied to evaluate the interplay of all the variables.