Dose Changes
The primary outcome was to determine which characteristics led to enoxaparin dose changes in pediatric patients (Table 3). Results of the multiple logistic regression analysis showed that patients aged 2-5.9 months (p=0.026), critical care status (p=0.009), and of Native American ethnicity (p = 0.016) were likely to have an enoxaparin dose change at least once during their treatment regimen guided by anti-Xa levels. Characteristics generally thought to lead to dose changes such as age 6-11.9 months, AKI, and BMI > 95 percentile were not statistically significant. These groups did have a smaller sample size, therefore potentially leading to an inability to find a significant correlation. Furthermore, the average starting dose of enoxaparin was 1.1 mg/kg/dose and the average number of dose changes were about 2 per patient (Table 4).